@article {803,
	title = {Quantifying the reliability of image replication studies: the image intraclass correlation coefficient (I2C2).},
	journal = {Cogn Affect Behav Neurosci},
	volume = {13},
	year = {2013},
	month = {2013 Dec},
	pages = {714-24},
	abstract = {<p>This article proposes the image intraclass correlation (I2C2) coefficient as a global measure of reliability for imaging studies. The I2C2 generalizes the classic intraclass correlation (ICC) coefficient to the case when the data of interest are images, thereby providing a measure that is both intuitive and convenient. Drawing a connection with classical measurement error models for replication experiments, the I2C2 can be computed quickly, even in high-dimensional imaging studies. A nonparametric bootstrap procedure is introduced to quantify the variability of the I2C2 estimator. Furthermore, a Monte Carlo permutation is utilized to test reproducibility versus a zero I2C2, representing complete lack of reproducibility. Methodologies are applied to three replication studies arising from different brain imaging modalities and settings: regional analysis of volumes in normalized space imaging for characterizing brain morphology, seed-voxel brain activation maps based on resting-state functional magnetic resonance imaging (fMRI), and fractional anisotropy in an area surrounding the corpus callosum via diffusion tensor imaging. Notably, resting-state fMRI brain activation maps are found to have low reliability, ranging from .2 to .4. Software and data are available to provide easy access to the proposed methods.</p>},
	keywords = {Adult, Brain, brain mapping, Computer Simulation, Female, Humans, Male, Models, Biological, Neuroimaging, Reproducibility of Results, Statistics as Topic},
	issn = {1531-135X},
	doi = {10.3758/s13415-013-0196-0},
	author = {Shou, H and Eloyan, A and Lee, S and Zipunnikov, V and Crainiceanu, A N and Nebel, N B and Caffo, B and Lindquist, M A and Crainiceanu, C M}
}
@article {rectalab,
	title = {Quantification of the spatial distribution of rectally-applied surrogates for microbicide and semen in colon with SPECT imaging},
	journal = {Accepted in the British Journal of Clinical Pharmacology},
	year = {2012},
	author = {Cao, Y and Caffo, B and Fuchs, E and Lee, L and Du, Y and Li, L and Bakshi, R and Khan, W and Wahl, R and Grohskopf, L and Hendrix, C}
}
@article {nazarian:qrs,
	title = {QRS Prolongation in Myotonic Muscular Dystrophy and Diffuse Fibrosis on Cardiac Magnetic Resonance},
	journal = {Magnetic Resonance in Medicine, PMCID: PMC3034129},
	volume = {64},
	number = {1},
	year = {2010},
	pages = {107{\textendash}114},
	author = {Nazarian, S and Bluemke, D and Wagner, K and Zviman, M and Turkbey, E and Caffo, B and Shehata, M and Edwards,D and Butcher, B and Calkins, H and Berger, R and Halperin, H and Tomaselli, G}
}
@article {boatman,
	title = {Quantifying Auditory Event-Related Responses in Multichannel Human Intracranial Recordings},
	journal = {Invited submission to Frontiers in Computational Neuroscience, PMCID: PMC2859880},
	volume = {4},
	number = {4},
	year = {2010},
	pages = {1{\textendash}17},
	author = {Boatman-Reich, D and Franaszczuk, Piotr J. and Korzeniewska, A. and Caffo, B and Ritzl, E and Colwell, S and Crone, N}
}
@article {ndovi2006quantitative,
	title = {Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method},
	journal = {Clinical Pharmacology \& Therapeutics},
	volume = {80},
	number = {2},
	year = {2006},
	pages = {146{\textendash}158},
	publisher = {Nature Publishing Group},
	author = {Ndovi, T and Choi, L and Caffo, B and Parsons, T and Baker, S and Zhao, M and Rohde, C and Hendrix, C}
}
